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4 Oxidative stress in gastric cancer 4.1 Gastric carcinogenesis Under oxidative stress, increased ROS in cells may harm tissues and trigger carcinogenesis, especially in the gastrointestinal system ( Figure 3 )

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While Metformin inhibits complex 1 of the respiratory chain in the mitochondria leading to an increase in adenosine monophosphate (AMP) and activation of AMP-activated protein kinase (AMPK), which in turn inhibits hepatic gluconeogenesis, the concentration of Metformin needed to achieve such effects in humans is supra-therapeutic (71, 72)