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Tirzepatide side effects The side effects of tirzepatide include: Very common feeling sick (nausea) diarrhoea constipation low blood sugar, if used alongside other diabetes treatments Common being sick (vomiting) reduced appetite indigestion tummy pain low blood pressure bloating dizziness hair loss reflux or heartburn feeling tired fast pulse burping or gas injection site reactions (itching or redness) increased level of pancreatic enzyme lipase in blood increased level of calcitonin in blood a decrease in appetite gallstones Uncommon side effects pain at the injection site infection of the gallbladder gastroparesis (delayed stomach emptying, causing bowel obstruction) an inflamed pancreas (acute pancreatitis) speak to your doctor if you get severe stomach or lower back pain an increased level of calcitonin (a hormone that helps to metabolise calcium) in the bloodstream fast pulse increased levels of the pancreatic enzyme amylase change in tase skin sesnsation changes delay in stomach emptying If you get tirzepatide side effects, speak to your doctor if they dont go away or bother you too much

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The authors thank Professor Patricia Brubaker, Departments of Physiology and Medicine, Canada Research Chair in Vascular and Metabolic Biology, University of Toronto for critical reading of the manuscript