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Evidence that Alzheimer's disease is a microvascular disorder: the role of constitutive nitric oxide

These authors showed distinct cellular expression in most layers of the neocortex along with specific and selective staining in the dentate gyrus and CA regions of the hippocampus, as well as in the Purkinje cell layer of the cerebellum

The induction of the antimicrobial peptide gene expression is mostly initiated by binding of transcription factors like NF- B, AP-1, and STAT3 [26] due to activation of Toll-like receptors by microbial antigens or initiated by cytokines [27]

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