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This results in activation of two major canonical signaling pathways: the IRS-1/PI3K/Akt pathway, which is linked to most metabolic actions, such as stimulation of glucose uptake, lipogenesis, glycogen synthesis, and inhibition of gluconeogenesis, and the Shc/Grb2/Sos/Ras/Raf/MAPK pathway, which regulates cell growth and differentiation (5, 7)