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Oral melanoacanthosis (melanoachantoma): report of a case and review of the literature

Since sirtuins like SIRT1 and SIRT3 are essential for PGC-1-mediated mitochondrial biogenesis and antioxidant defense, supplementation with NAD+ precursors such as niacin, nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN) aims to boost NAD+ levels, activate sirtuins, and enhance mitochondrial function