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In vitro studies indicated that the primary enzyme responsible for the limited metabolism of sitagliptin was CYP3A4, with contribution from CYP2C8

Proteases rapidly degrade many peptides, exhibit poor oral bioavailability due to enzymatic breakdown in the digestive tract, and suffer from short systemic half-lives, reducing their clinical efficacy

Tendontendon continuities were reported to have re-established well, with no ossicles forming in other tissues [94,95,96,97,98] (note, with bone morphogenetic proteins (BMPs) [126,127,128], the initial tendon healing process is misleading, due to its similarity to the process of fracture healing [126] and the formation of ossicles in other tissues [126,127,128])

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