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This narrative review synthesizes current preclinical and human evidence on the bidirectional interactions between GLP-1 RAs and the intestinal microbial ecosystem, with particular attention to microbial composition, metabolite production (including short-chain fatty acids and bile acids), intestinal barrier integrity, and inflammatory signaling

& Donnelly, J

Therefore, patients identified with a high inflammatory state using markers like PNI or GPS may be the primary beneficiaries of immunonutrition