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Its compounding-pathway status is unsettled: ibutamoren mesylate was nominated for inclusion on FDA's Section 503A bulk drug substances list, and the Pharmacy Compounding Advisory Committee reviewed the nomination at its October 29, 2024 meeting and voted against recommending it for the list, citing concerns about the strength of the safety and efficacy evidence

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In some people with restless legs syndrome, anemia due to iron deficiency may be a contributing factor, while in others restless legs syndrome has been linked to pregnancy, diabetes, multiple sclerosis, rheumatoid arthritis, kidney failure, varicose veins or peripheral neuropathy (nerve damage in the hands and feet)