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Injections of GLP-1 receptor agonists, on the other hand, lead to more sustained elevations of GLP-1 blood levels since they circumvent the gastrointestinal tract
The result is increased vulnerability to infections, potential liver toxicity, and a long list of side effects that many patients find difficult to tolerate over years or decades of treatment
Antibiotics such as levofloxacin or ciprofloxacin may reduce L-Carnitine absorption
A prospective proof-of-concept study by Nicolau et al 19 found that liraglutide treatment for three months resulted in a decrease in BMI (from 39.3 to 35.6 kg/m 2 ), waist circumference (from 121.3 to 110.6 cm), mean Hurley stage (from 2.6 to 1.1), DLQI (from 12.3 to 9.7), Beck Depression Inventory (BDI) (from 22 to 16.7), and visual analog scale (VAS) for pain (from 5.6 to 3.2), as well as a decrease in inflammatory markers such as CRP (from 4.5 to 3 mg/dL), homocysteine (from 16.2 to 13.3 mol/L), plasma morning cortisol (from 15.9 to 12.6 g/dL), and insulin (from 18.9 to 15.7 U/mL)
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