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The non-canonical anti-RNA viral function of cGAS is independent of its nucleotidyltransferase and DNA-binding activities, suggesting that cGAS acts as an antiviral cytosolic DNA sensor (DNA virus) or co-transcription factor (RNA virus)

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For BPC-157, the agency cited the potential for immunogenicity, peptide-related impurities, problems characterizing the active ingredient, and a lack of safety data for the proposed routes of administration