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These results are supported by a recent randomized placebo controlled trial, which demonstrated that a 6-week sulforaphane intervention (30 mg/day) safely improved depressive symptoms, as measured by the Hamilton Rating Scale for Depression, in 66 participants with a history of a cardiac procedure and presence of mild to moderate depression (Ghazizadeh-Hashemi et al., 2021)

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Yet, compared to subjects with adequate selenium status, selenium-deficient individuals might be more susceptible to additional physiological stresses (48)