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5.4.2 Effects on liver Despite the lack of expression of GIPR (41, 191) and GLP-1R (192, 193) in hepatocytes, both GIP and GLP-1 have indirect effects on hepatic lipid and glucose metabolism (194)

NICE recommends that patients receive support from a multidisciplinary team delivering comprehensive weight management programs, emphasizing calorie restriction, increased physical activity, and behavioural interventions for long-term success by trained professionals [7]

In type 2 diabetics, the HbA1c decrease, a blood sugar marker, spanned 1.3 to 2.0% in the studies, depending on dose

Iron status deserves particular attention in menstruating women, as monthly blood loss combined with reduced dietary intake can deplete stores rapidly