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The preclinical side effect profile is favorable over 4 weeks: no pathological cardiac hypertrophy (some ERRalpha myocardial effects are physiological, dose is calibrated to remain in the adaptive range), no hepatic toxicity, no mitogenic signal at tested doses

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this enzymeprodrug strategy eradicated patient-derived tumours in mice and markedly prolonged survival compared with standard cisplatin/paclitaxel [175]