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As a water-soluble vitamin, excess B12 is typically excreted in urine rather than accumulating to toxic levels

Tell your doctor about all prescription, nonprescription, illegal, recreational, herbal, nutritional, or dietary drugs youre taking before starting on levothyroxine

Phosphoribosyl pyrophosphate synthetase 1 (PRPS1), the key enzyme of the de novo nucleotide synthesis pathway, is O -GlcNAcylated by O -GlcNAc transferase (OGT), which triggers PRPS1 hexamer formation and relieves nucleotide product-mediated feedback inhibition, thereby boosting PRPS1 activity