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Vitamin A toxicity presenting as bone pain

Moreover, an open, single-arm, first-in-human trial of PU-H71 in patients with advanced solid tumors showed that the incidence of grade 2 adverse events such as common nausea, headache, and fatigue was extremely low, and only one patient exhibited a grade 3 adverse event (vomiting) that could be related to PU-H71

Participants were still actively losing weight at week 48

265 p38 MAPK and GSK3 have also been reported to phosphorylate SRC-3 on ser869 and ser505, which not only enhances its binding ability with AR but also determines the mode of action through ubiquitination