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The nasal route also offers a direct portal to deliver substances directly into the brain via neuron pathways without being encumbered by the limitations of the blood-brain barrier

Neuroprotective efficacy was evidenced by a 62% reduction in the loss of tyrosine hydroxylase+ neurons in the substantia nigra and substantial recovery of striatal dopamine and metabolites

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Characterized mutations in CARD14 cause gain-of-function consequences, which result in increased production of pro-inflammatory cytokines and sustained activation of NF-B (Berki et al