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It is generally recommended to avoid using saline or Phosphate Buffered Saline (PBS) for the initial high-concentration stock, as salts can sometimes promote peptide aggregation

The side effect profiles differ between semaglutide and tirzepatide , so switching medications is sometimes the solution

In fact, in head-to-head studies, Tirzepatide not only lowered HbA1c more effectively than existing medications like semaglutide, but also helped patients lose more body weight, with some losing over 20% of their total body weight in extended trials