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The leptin receptor activates Janus kinase 2 and signals for proliferation in a factor-dependent cell line

In the case of pronounced absorption disorders, for example as a result of gastritis or after removal of the small intestine, in Crohn's disease, diverticulosis and the so-called blind-loop syndrome, there is a gradual decrease in the vitamin B12 store in the liver, which can turn into a manifest vitamin B12 deficiency

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Cell metabolism in cancers is extremely active to obtain sufficient nutrients to meet the high demands of energy and resources (Zhao et al., 2023)