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Serious side effects reported include: Long-Term Effects and Concerns: Research links long-term GLP-1 agonist use with increased risk of gallbladder and biliary diseases, and concern remains about other serious adverse reactions that patients may not be warned about

Diabetologia (2017) 60(8):13909

Weight Loss: The Data At this time, there arent any published head-to-head obesity trials directly comparing oral semaglutide to orforglipron, says Maria Teresa Anton, MD, a board-certified internal medicine physician who specializes in endocrinology, diabetes, and metabolism with Pritikin Longevity Center in Miami