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Abstract Pyroglutamic acidemia (oxoprolinemia) is an underrecognized cause of high anion gap acidosis resulting from derangement in the gamma-glutamyl cycle

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The presence of increased levels of oxidized dopamine and lower glucocerebrosidase activity, in turn promotes S accumulation ( Although direct interconnections between the release of pro-inflammatory cytokines and S accumulation have yet to be established, altered pro-inflammatory cells in experimental PD models suggest that inflammation and S dysregulation are closely interconnected (Tan et al., 2020)