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The extent of weight loss likely also reflects the potency of anti-inflammatory effect, and biomarkers indicative of reduced inflammation have been shown to precede wight loss in multiple trials of this drug class

Pediatr Res 38:324331 Poorthuis BJ, Jille-Vlckova T, Onkenhout W (1993) Determination of acylcarnitines in urine of patients with inborn errors of metabolism using high-performance liquid chromatography after derivatization with 4-bromophenacylbromide

Additionally, as muscle mass can decline during rapid weight loss if not paired with resistance training, you lose another source of metabolic heat production

Listen to GNL Podcast Episode 14: Overcoming Insulin Resistance