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doi: 10.3389/fmicb.2023.1276951 Received 13 August 2023 Accepted 16 November 2023 Published 04 December 2023 Volume 14 - 2023 Edited by Suman S

Anesthesia was initiated intramuscularly (4.4 mg/kg telazol and 2.2 mg/kg xylazine) and subsequently maintained with an inhaled halogenated anesthetic (isoflurane, 0.75-3.0%)

The further two-sample t -tests, also considering the FDR (Table S2 e S3), evidenced ten metabolites (3-hydroxybutyrate, isoleucine, alanine, valine, acetone, acetoacetate, leucine, lactate, phenylalanine, acetate) as significantly changed in the plasma, and three (acetoacetate, succinate and 3-hydroxybutyrate) in the pericardial fluid of IHD patients in comparison with controls, highlighted by the red dotted circle in VIP scores models in Fig

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