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For example, a meta-analysis found that two copies of the MTHFR C677T variant (A/A, homozygous) increase the relative risk of heart disease by 38%.[ref][ref] However, not all studies agree, and a large prospective study (n=6,000) found that older people with two copies of the C677T allele were at a 30% decreased risk of death from cardiovascular disease when other parameters were included.[ref] The increased risk is not just due to high homocysteine

The authors found that ascorbate predominates in neurons (10 mM), whereas GSH is slightly predominant in glia

Zhan M, Brooks C, Liu F, Sun L, Dong Z (2013) Mitochondrial dynamics: regulatory mechanisms and emerging role in ren al pathophysiology