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An RNA aptamer, Apt-1, was developed to specifically target the extracellular sheddase domain of the metalloproteinase Adam8, which plays a critical role in maintaining the myofibroblast-like cancer-associated fibroblast (myCAF) phenotype and cancer stemness in breast (MDA-MB-231) and liver (HepG2) cancer models

Exertional heat stroke is more common in military personnel and young adults performing high-intensity physical work in hot and humid environments [8]

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The peptide supports but does not replace fundamental healing requirements like appropriate rest, physical therapy, and proper nutrition