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The analysis led to generally consistent results, which were similar to the primary analysis between cohorts of new users of GLP-1RAs compared with new users of SGLT2 inhibitors, metformin or other second- or third-line medications

The effects on embryo development (Fig

Less common but serious side effects included abnormal heart rhythm

Recent preclinical studies have demonstrated that central GIP receptor activation can attenuate the aversive effects, such as nausea and vomiting, typically induced by GLP1 receptor agonism 29