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This step has 5-hydroxy-L-tryptophan as substrate, pyridoxal 5-phosphate as an optional activator, and is influenced by Al 3+ , Zn 2+ , Ca 2+ , and Mg 2+ levels

Figure 3 below summarizes these processes, highlighting the interplay between bacterial infection, immune mediators (e.g., TNF-, IL-6, transforming growth factor-beta [TGF-], IL-10), and cellular actors (e.g., neutrophils, M1/M2 macrophages, fibroblasts, keratinocytes, endothelial cells) during wound healing [43, 48]

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Int J Mol Sci 20(10):2407 Liu X et al (2022) Oxidative stress in autism spectrum disordercurrent progress of mechanisms and biomarkers