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Adults with BMI 27 plus at least one weight-related comorbidity (symptomatic heart failure with preserved ejection fraction, metabolic dysfunction-associated steatohepatitis)

doi: 10.1056/NEJMoa1509225 54 PollockC.StefanssonB.ReynerD.RossingP.SjostromC

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This mitochondrial fraction is functionally critical, as demonstrated by the restoration of ferroptosis sensitivity in CHAC1-null cells through expression of a mitochondrially targeted CHAC1 (Ward et al., 2024)