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Severe Disease & Prevention Research continues to focus on Tradjentas efficacy in preventing long-term microvascular complications (such as kidney damage and nerve pain) and macrovascular complications (heart attack and stroke)

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Strongest clinical signal: Dermatologic topical/oral GSH shows short-term melanin index improvements in small RCTs, but durability and long-term safety are uncertain

Stress management techniques like meditation, therapy, or cold exposure reduce cortisol and support endocrine health