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Finally, though carotid plaque assessment by ultrasound is a surrogate marker, it has now been validated as a meaningful predictor of cardiovascular events, with robust recommendations on the performance, standardization and clinical utility in the prediction of important atherosclerotic outcomes [19]

These injections are recommended to be administered over a 10 week period

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Funding This work was supported by the European Commission (project PROMETEUS, grant 823780), the Portuguese Fundao para a Cincia e a Tecnologia (FCT) (PhD fellowship DFA/BD/8167/2020), FEDER and National Funds (project eZVac, grant LISBOA2030-FEDER-00754700), iNOVA4HealthProgramme in Translational Medicine (UID/04462), financially supported by FCT/Ministrio da Educao, Cincia e Inovao and the Associate Laboratory LS4FUTURE (LA/P/0087/2020)