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NICE recommends reducing salt intake, eating more fruits, vegetables, and wholegrains, and considering a Mediterranean-style diet pattern Leafy green vegetables such as spinach, rocket, and lettuce provide dietary nitrates similar to beetroot but in smaller, more manageable amounts Pomegranate juice has demonstrated modest blood pressure-lowering effects in some studies, though evidence quality varies

Long-term follow-up studies are needed to assess durability of therapeutic effects and to identify any delayed adverse effects or complications that might not be apparent in shorter-term investigations

A supervised protocol with a progressive dosing ramp and provider monitoring produces outcomes that self-directed use rarely achieves

Misoprostol, an FDA-approved prostaglandin analog, prevents NSAID-induced ulcers with a number needed to treat (NNT) of approximately 8 based on the MUCOSA trial 12