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According to data from the 72-week SURMOUNT-1 trial, participants on the maximum dose experienced an average weight loss of 18% of their body weight , with 36.2% achieving a significant reduction in weight[1]

During sepsis, intracellular Fe 2+ levels significantly increase, whereas the expression of the iron storage protein FTH1 decreases and the expression of the iron uptake receptor TFR1 increases, collectively exacerbating intracellular iron accumulation (Wang et al., 2018

A smaller study 168 exposed pregnancies showed the same result

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