Secondary endpoints and related outcome measures 1
Briefly, when muscle is injured, overused, or mechanically stretched, satellite cells are activated to enter the cell cycle through a cascade of events including nitric oxide (NO) radical-dependent release of the active form of HGF (a hetero-dimer of - and -chains) from its extracellular tethering and the subsequent presentation of HGF to the cell-membrane signaling receptor c-met, followed by the sequence of steps including proliferation to produce myoblast progeny, differentiation, and fusion with existing muscle fibers and/or to form new fibers 18,19,20,21,22, 31
doi: 10.3389/fpsyt.2019.00647 Received 28 January 2019 Accepted 12 August 2019 Published 10 September 2019 Volume 10 - 2019 Edited by Carolina Baeza-Velasco, Universit Paris Descartes, France Reviewed by Nawaporn Vinayavekhin, Chulalongkorn University, Thailand
The severe symptoms occurred following a bout of particularly excessive ethanol intake