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Targeting IGF1 to alleviate obesity through regulating energy expenditure and fat deposition

The International Journal of Developmental Biology, 62 (6-7-8), 491-505

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Under physiological conditions, it supports synaptic plasticity [346], whereas under pathological states, such as during astrocytic necroptosis, proBDNF may exert neurotoxic effects and promote apoptotic signaling [349]