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The Supplement Facts serving size is 1 capsule, but the brand recommends 2 daily

Since CERT1 is a cytosolic target and cytosolic proteasome is estimated to be less abundant than nuclear proteasome (170 nM versus 900 nM 63 ), it is likely that both CERT1 and cytosolic proteasomal saturations by chimeras are responsible for the observed effect

The latter is then either irreversibly reduced to 5-methylTHF or serves as the one-carbon donor in the synthesis of nucleic acids, where it is required by thymidylate synthetase in the conversion of deoyxuridine to deoxythymidine for pyrimidine biosynthesis or is converted to other folate cofactor forms essential for purine biosynthesis