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[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Mann J.F.E., rsted D.D., Brown-Frandsen K., Marso S.P., Poulter N.R., Rasmussen S., Torne K., Zinman B., Buse J.B

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Some protocols use a 'loading' phase (higher dose for 35 days) followed by maintenance dosing (lower dose long-term), based on the hypothesis that initial synaptogenesis requires stronger signaling, while maintaining new synapses requires less

Figure 4 3.3.4 Potential to prevent cancer cachexia Cancer cachexia is a syndrome characterized by weight loss, skeletal muscle loss, and metabolic disturbances, commonly seen in patients with advanced tumors