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Eur J Intern Med 63:914 Berlie H, Hurren KM, Pinelli NR (2012) Glucagon-like peptide-1 receptor agonists as add-on therapy to basal insulin in patients with type 2 diabetes: a systematic review

GLP-1 receptor stimulation has been shown to preserve cortical and dopaminergic neurons in models of stroke and Parkinsonism, and broader reviews describe GLP-1 mimetics as neuroprotective agents that reduce oxidative stress, inflammation, and metabolic strain while supporting neuronal resilience [23,24]

Many enzymes rely on active thiol (-SH) groups to maintain their biological activity

Company-reported Phase 3 topline results have circulated in 20252026, and a regulatory filing has been anticipated, but retatrutide is not FDA- or EMA-approved and is not available as a prescription product