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Following rigorous quality control measures, which included the exclusion of duplicate entries, reports with incomplete demographic data (age or gender), and cases with missing temporal information, we retained 13,047 AE reports associated with concomitant GLP-1 receptor agonist and metformin therapy for final analysis

However, these gastrointestinal side effects were observed during dosage escalation

A two-year carcinogenicity study was conducted in male and female mice given oral doses of sitagliptin of 50, 125, 250, and 500 mg/kg/day

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