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Chem Res Toxicol 2003;16:295303 [DOI] [PubMed] [Google Scholar] 29.Chen C, Krausz KW, Shah YM, Idle JR, Gonzalez FJ.Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity

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Fasting induces a metabolic shift from glucose utilization to fatty acid oxidation and ketone body production as primary energy sources