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Mutations in this gene lead to ClbA formation [108]

10.1371/journal.pone.0126978 156 TianM.von DahlC

Disruption of SUMOylation has been implicated in AD, HD and PD, where it contributes to protein aggregation, synaptic dysfunction, and neuronal vulnerability

[12] The more severe form, called "colonic inertia", is the condition in which eating and prokinetics does not lead to increase in motor activity and HAPCs