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Key data from these trials are summarized inse drugs have not been rigorously evaluated in CKD and T2D and so are not indicated for use in CKD in the United States

Phenylephrine and pseudoephedrine decongestants may elevate blood pressure or heart rate, effects that overlap with semaglutide's cardiovascular monitoring needs

They introduce additional CQAs that must be carefully monitored, including the proportion of conjugated versus unconjugated peptide, the presence of free form of the conjugate moiety (e.g., lipids, PEG chains), and the occurrence of di- or poly-PEGylation

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