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This article will address the question of what is the MTHFR gene mutation, how it impacts our health and what can we do if we have an alteration in this gene

That does not guarantee an individual will lose more on the second drug, but average response is higher

[1] In the pivotal SURMOUNT-1 clinical trial, musculoskeletal complaints such as back pain, arthralgia, and myalgia were reported but did not occur at significantly higher rates than in the placebo group