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however, the exact mechanism of its neuroprotective action requires further investigation [87,88]

The extensive use of urban lighting has profoundly transformed natural nighttime darkness, creating light pollution. Data indicate that over 80% of the global population resides in areas experiencing substantial light pollution, with these regions expanding at an annual rate of 2.2% ( Exposure levels vary across populations

At the epidemiological observation level, prospective cohort studies have confirmed the predictive value of baseline metabolite concentrations for subsequent disease progression, with current evidence strength graded as moderate (159)