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In summary, our extensive screening of 5170 drugs using HTS techniques led to the discovery of six new drugs, among which aminoacridine, abemaciclib, and the combination of aminoacridine with MXD showed promising results in animal models

TB-500 represents a synthetic form of the active region of thymosin beta-4, a protein involved in cellular structural dynamics and regulatory signalling systems

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Animal LAD and MCAO experiments For LAD and MCAO experiments, male C57BL/6 J mice aged 812 weeks were ordered from Charles River Laboratories UK (Margate, UK) and were housed in individually ventilated cages and maintained under controlled temperature (22 2 C) on a 12 h light/dark cycle with ad libitum access to chow and water