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FIGURE 4 Novel drug modalities for NRF2 activation Up to date, the only NRF2 activators in clinical use are DMF for MS (Rosito et al., 2020), and more recently Omaveloxolone, a semisynthetic terpenoid with potent NRF2-activating effects gained FDA approval in Februrary 2023 for the treatment of Friederichs ataxia ( However, most NRF2 activators are of electrophilic nature and exhibit unpredictable poly-pharmacology

Stancheva R, Paunova-Krasteva T, Topouzova-Hristova T, Stoitsova S, Petrov P, Haladjova E

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Historically, surgery has been the most established and preferred method for cancer treatment, while radiation therapy was first employed to treat localized cancers in the 1960s (Khan et al., 2019)