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It has a well-established FDA-recognized role in the prevention and treatment of nausea and vomiting in the following conditions: Pregnancy : Pyridoxine is a first-line therapy for patients with morning sickness during pregnancy and is part of the FDA-approved prescription combination doxylamine + pyridoxine

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Other important safety considerations include: Risk of acute pancreatitis : Seek urgent medical attention for severe, persistent abdominal pain with or without vomiting [1] Gallbladder disease : Increased risk of gallstones and related complications Diabetic retinopathy : Caution in patients with pre-existing retinopathy due to rapid improvement in blood glucose control Hypoglycaemia : Increased risk when used with insulin or sulfonylureas, which may require dose reduction of these medications Oral contraceptive interaction : Reduced effectiveness due to delayed gastric emptying