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This technique is rooted in the classical experiments of Walther Otto Ernst Friedrich (18831958), Paul Knipping (18831935), and Max von Laue (18791960), who, in 1912, showed that the X-rays passing through a crystal produced a diffraction pattern on a photographic plate (Friedrich et al., 1912)

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In 2009, the EMEA (European Medicine Agency) withdrew market authorisation for rimonabant in all countries of the European Union due to safety concerns [21]