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Data derived from a retrospective survey of 245 patients with IBD suggest that the prevalence of bone fractures in people with ulcerative colitis and Crohns disease is unexpectedly high, particularly in patients who have a long duration of disease, frequent active phases, and high cumulative doses of glucocorticoid intake (Miheller 2010

The activated NF- B rapidly translocated from the cytoplasm into the nucleus, binds to specific DNA sequences, induces the expression of several proinflammatory cytokine genes, and promotes the massive release of proinflammatory cytokines such as TNF- , IL-1, and IL-6 (Xu et al., 2022)

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