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For instance, our group recently showed that a mutation in the ribosomal RPL10 gene, known as RPL10 R98S, enhances serine/glycine synthesis in T-cell leukaemia by increasing both PSPH transcriptional and translational levels (3)

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Further visual inspection in VIDA of the vBrood search for candidates that can fill the doorstop pocket led us, among other possible scaffolds, to pinane in subpocket C

However, its clinical utility remains uncertain due to heterogeneity in outcomes, possible isomer-specific effects, genetic interactions, and methodological variability across studies