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High-Fiber, whole-food dietary intervention alters the human gut microbiome but not fecal short-chain fatty acids

In September 2024 the BLA rolling submission process was completed and the BLA officially filed November 2024 with a PDUFA action date of September 5, 2025

Fatima Cody Stanford, associate professor of medicine and pediatrics at Harvard Medical School, said by reducing weight, patients may experience less joint pain and inflammation, improved mobility, and reduced disease activity

These studies indicate that the system influences the expression of genes along the GLP-1 pathway in L-cells, upregulating genes like GCG and PCSK1, which are crucial for GLP-1 synthesis