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Importantly, LONP1 deficiency activates the PI3KAkt pathway, increasing fibroblast growth factor 2 (FGF2) expression twofold, which promotes myofibroblast transformation and collagen deposition [71]

Specifically, as discussed previously with respect to criteria at 419.66(b)(3), we noted that it is unclear whether other available insertion instruments may be used to implant the aprevo implant and, for the aprevo Cervical ACDF-X system, whether any or all of the integrated fixation screws may be replaced with other commercially available screws

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Additionally, hybrid scaffolds of electrospun scaffolds and hydrogels can also be fabricated